Protein structures

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NMR protein structures co-authored by P. Güntert.

5n6r.pdb-500.jpg Reckel, S., Gehin, C., Tardivon, D., Harduin, D., Georgeon, S., Kükenshöner, T., Löhr, F., Koide, A., Buchner, L., Panjkovich, A., Reynaud, A., Pinho, S., Gerig, B., Svergun, D., Pojer, F., Güntert, P., Dötsch, V., Koide, S., Gavin, A.-C. & Hantschel, O. Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat. Commun. 8, 2101 (2017)

PDB 5N6R NMR restraints BMRB 34101 (DH NMR structure)
PDB 5N7E (DH/Mb(Bcr-DH_4))
PDB 5OC7 (PH/Mb(Bcr-PH_4))

2N5E asym r 500.jpg Bibow, S., Polyhach, Y., Eichmann, C., Chi, C. N., Kowal, J., Albiez, S., McLeod, R. A., Stahlberg, H., Jeschke, G., Güntert, P. & Riek, R. Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I. Nat. Struct. Mol. Biol. 24, 187-193 (2017)

PDB 2N5E NMR restraints BMRB 25710

5gvq.pdb-500.jpg Kuwasako, K., Nameki, N., Tsuda, K., Takahashi, M., Sato, A., Tochio, N., Inoue, M., Terada, T., Kigawa, T., Kobayashi, N., Shirouzu, M., Ito, T., Sakamoto, T., Wakamatsu, K., Güntert, P., Takahashi, S., Yokoyama, S. & Muto, Y. Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment. Protein Sci. 26, 280-291 (2017)

PDB 5GVQ NMR restraints BMRB 36018

2N9L asym r 500.jpg Ikeya, T., Hanashima, T., Hosoya, S., Shimazaki, M., Ikeda, S., Mishima, M., Güntert, P. & Ito, Y. Improved in-cell structure determination of proteins at near-physiological concentration. Sci Rep. 6, 38312 (2016)

PDB 2N9L NMR restraints BMRB 25910

2NB1 asym r 500.jpg Gebel, J., Luh, L. M., Coutandin, D., Osterburg, C., Löhr, F., Schäfer, B., Frombach, A., Sumyk, M., Buchner, L., Krojer, T., Salah, E., Mathea, S., Güntert, P., Knapp, S. & Dötsch, V. Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization. Cell Death Diff. 23, 1930-1940 (2016)

PDB 2NB1 NMR restraints BMRB 25958

2NAO bio r 250.jpg Wälti, M. A., Ravotti, F., Arai, H., Glabe, C., Wall, J., Böckmann, A., Güntert, P., Meier, B. H. & Riek, R. Atomic resolution structure of a disease-relevant Aβ(1–42) amyloid fibril. Proc. Natl. Acad. Sci. USA

PDB 2NAO NMR restraints BMRB 26692

2MYX bio r 250.jpg von Delbrück, M., Kniss, A., Rogov, V. V., Pluska, L., Bagola, K., Löhr, F., Güntert, P., Sommer, T. & Dötsch, V. The CUE domain of Cue1 aligns growing ubiquitin chains with Ubc7 for rapid elongation. Mol. Cell 62, 918-928 (2016)

PDB 2MYX NMR restraints BMRB 25461

2MWX bio r 250.jpg Huang, S. Y., Chang, C. F., Fan, P. J., Naik, M. T., Güntert, P., Shih, H. M. & Huang, T. H. The RING domain of human promyelocytic leukemia protein (PML). J. Biomol. NMR 61, 173-180 (2015)

PDB 2MWX NMR restraints BMRB 25376

2MVX bio r 250.jpg Schütz, A. K., Vagt, T., Huber, M., Ovchinnikova, O. Y., Cadalbert, R., Wall, J., Güntert, P., Böckmann, A., Glockshuber, R., and Meier, B. H. Atomic-resolution three-dimensional structure of amyloid β fibrils bearing the Osaka mutation. Angew. Chem. Int. Ed. 54, 331–335 (2015)

PDB 2MVX NMR restraints BMRB 25289

2RUG bio r 250.jpg Tsuda, K., Kuwasako, K., Nagata, T., Takahashi, M., Kigawa, T., Kobayashi, N., Güntert, P., Shirouzu, M., Yokoyama, S. & Muto, Y. Novel RNA recognition motif domain in cytoplasmic polyadenylation element binding protein 3. Proteins 82, 2879–2886 (2014)

PDB 2RUG NMR restraints BMRB 11563

2RU3 bio r 250.jpg Kuwasako, K., Takahashi, M., Unzai, S., Tsuda, K., Yoshikawa, S., He, F., Kobayashi, N., Güntert, P., Shirouzu, M., Ito, T., Tanaka, A., Yokoyama, S., Hagiwara, M., Kuroyanagi, H. & Muto, Y. RBFOX and SUP-12 sandwich a guanine base to cooperatively regulate tissue-specific splicing. Nat. Struct. Mol. Biol. 21, 778–786 (2014)

PDB 2RU3 NMR restraints BMRB 11517 (SUP-12–RNA6 complex)
PDB 2MGZ NMR restraints BMRB 11518 (ASD-1–SUP-12–RNA12 complex)

2MMJ bio r 250.jpg Uggerhøj, L. E., Munk, J. K., Hansen, P. R., Güntert, P. & Wimmer, R. Structural features of peptoid-peptide hybrids in lipid-water interfaces. FEBS Lett. 588, 3291–3297 (2014)

PDB 2MMJ NMR restraints BMRB 19856 (M-Nleu11)
PDB 2MN9 NMR restraints BMRB 19883 (M-Nleu13 trans)
PDB 2MN8 NMR restraints BMRB 19882 (M-Nleu13 cis)

2RU5 bio r 250.jpg Watson, R. P., Christen, M. T., Bumbak, F., Ewald, C., Reichen, C. Mihajlovic, M., Schmidt, E., Güntert, P., Caflisch, A., Plückthun, A., Zerbe, O. Spontaneous self assembly of fragments of engineered Armadillo repeat proteins into a folded structure. Structure 22, 985–995 (2014)

PDB 2RU5 NMR restraints BMRB 11548 (uncomplexed MA)
PDB 2RU4 NMR restraints BMRB 11544 (MA-YM2 complex)

2MD9 bio r 250.jpg Tufar, P., Rahighi, S., Kraas, F. I., Kirchner, D. K., Löhr, F., Henrich, E., Köpke, J., Dikic, I., Güntert, P., Marahiel, M. A. & Dötsch, V. Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification. Chem. Biol. 21, 552–562 (2014)

PDB 2MD9 NMR restraints BMRB 19479

2RTX bio r 250.jpg Kogure, H., Handa, Y., Nagata, M., Kanai, N., Güntert, P., Kubota, K. & Nameki, N. Identification of residues required for stalled-ribosome rescue in the codon-independent release factor YaeJ. Nucl. Acids Res. 42, 3152-3163 (2014)

PDB 2RTX NMR restraints BMRB 11534

2M8I bio r 250.jpg Luh, L. M., Hänsel, R., Löhr, F., Kirchner, D. K., Krauskopf, K., Pitzius, S., Schäfer, B., Tufar, P., Corbeski, I., Güntert, P. & Dötsch, V. Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition. J. Am. Chem. Soc. 135, 13796−13803 (2013)

PDB 2M8I NMR restraints BMRB 19258 (wildtype WW domain)
PDB 2M8J NMR restraints BMRB 19259 (WW(S16E) mutant)

2LUE bio r 250.jpg Rogov, V. V., Suzuki, H., Fiskin, E., Wild, P., Kniss, A., Rozenknop, A., Kato, R., Kawasaki, M., McEwan, D. G., Löhr, F., Güntert, P., Dikic, I., Wakatsuki, S. & Dötsch, V. Structural basis for phosphorylation-triggered autophagic clearance of Salmonella. Biochem. J. 454, 459–466 (2013)

PDB 2LUE NMR restraints BMRB 18518 (NMR structure of LC3B OPTN-LIR Ptot complex)
PDB 3VTU (crystal structure of human LC3B_2-119)
PDB 3VTV (crystal structure of Optineurin LIR-fused human LC3B_2-119)
PDB 3VTW (crystal structure of T7-tagged Optineurin LIR-fused human LC3B_2-119)

2M99 bio r 250.jpg Lin, Y. J., Ikeya, T., Güntert, P. & Chang, L. S. NMR solution structure of a chymotrypsin inhibitor from the Taiwan cobra. Molecules 18, 8906-8918 (2013)

PDB 2M99 NMR restraints BMRB 19287

2DK6 bio r 250.jpg He, F., Tsuda, K., Takahashi, M., Kuwasako, K., Terada, T., Shirouzu, M., Watanabe, S., Kigawa, T., Kobayashi, N., Güntert, P., Yokoyama, S. & Muto, Y. Structural insight into the interaction of ADP-ribose with the PARP WWE domains. FEBS Lett. 586, 3858–3864 (2012)

PDB 2DK6 NMR restraints BMRB 11500 (WWE domain from PARP11)
PDB 1X4R NMR restraints BMRB 11501 (WWE domain from PARP14)

2LVL bio r 250.jpg Christ, N. A., Bochmann, S., Gottstein, D., Duchardt-Ferner, E., Hellmich, U. A., Düsterhus, S., Kötter, P., Güntert, P., Entian, K.-D. & Wöhnert, J. The first structure of a lantibiotic immunity protein, SpaI from Bacillus subtilis, reveals a novel fold. J. Biol. Chem. 287, 35286-35298 (2012)

PDB 2LVL NMR restraints BMRB 17534

2LUM bio r 250.jpg Vögeli, B., Kazemi, S., Güntert, P. & Riek, R. Spatial elucidation of motion in proteins by ensemble-based structure calculation using exact NOEs. Nature Struct. Mol. Biol. 19, 1053–1057 (2012)

PDB 2LUM NMR restraints BMRB 18531

2RSM bio r 250.jpg Kogure, H., Hikawa, Y., Hagihara, M., Tochio, N., Koshiba, S., Inoue, Y., Güntert, P., Kigawa, T., Yokoyama, S. & Nameki, N. Solution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65. Proteins 80, 2629–2642 (2012)

PDB 2RSM NMR restraints BMRB 11491

2RS6 bio r 250.jpg Nagata, T., Tsuda, K., Shirouzu, M., Kigawa, T., Kobayashi, N., Güntert, P., Yokoyama, S. & Muto, Y. Solution structures of the double-stranded RNA-binding domains from RNA-helicase A. Proteins 80, 1699–1706 (2012)

PDB 2RS6 NMR restraints BMRB 11456 (dsRBD1)
PDB 2RS7 NMR restraints BMRB 11457 (dsRBD2)

2LIW bio r 250b.jpg Busche, A., Gottstein, D., Hein, C., Ripin, N., Pader, I., Tufar, P., Eisman, E. B., Gu, L. Walsh, C. T., Sherman, D. H., Löhr, F., Güntert, P. & Dötsch, V. Characterization of the interaction between an ACP domain and a halogenase in the curacin A polyketide synthetase. ACS Chem. Biol. 7, 378–386 (2012)

PDB 2LIU NMR restraints BMRB 17906 (holo-ACPI)
PDB 2LIW NMR restraints chemical shifts (HMG-ACPI)

2DK4 bio r 250b.jpg He, F., Inoue, M., Kigawa, T., Takahashi, M., Kuwasako, K., Tsuda, K., Kobayashi, N., Terada, T., Shirouzu, M., Tanaka, A., Sugano, S., Güntert, P., Yokoyama, S. & Muto, Y. Solution structure of the Splicing Factor Motif (SFM) of the human Prp18 protein. Proteins 80, 968–974 (2012)

PDB 2DK4 NMR restraints BMRB 11355

2L6X bio r 250b.jpg Reckel, S., Gottstein, D., Stehle, J., Löhr, F., Verhoefen, M. K., Takeda, M., Silvers, R., Kainosho, M., Glaubitz, C., Wachtveitl, J., Bernhard, F., Schwalbe, H., Güntert, P. & Dötsch, V. Solution NMR structure of proteorhodopsin. Angew. Chem. Int. Ed. 50, 11942–11946 (2011)

PDB 2L6X NMR restraints BMRB 17327

2L8J bio r 250b.jpg Rozenknop, A., Rogov, V. V., Löhr, F., Güntert, P., Dikic, I., & Dötsch, V. Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1. J. Mol. Biol. 410, 477–487 (2011)

PDB 2L8J NMR restraints BMRB 17412

2KX7 bio r 250.jpg Schmöe, K., Rogov, V. V., Rogova, N. Y., Löhr, F., Güntert, P., Bernhard, F. & Dötsch, V. Structural insights into Rcs phosphotransfer: The newly identified RcsD-ABL domain enhances interaction with the response regulator RcsB. Structure 19, 577–587 (2011)

PDB 2KX7 NMR restraints

2RRB bio r 250.jpg Tsuda, K., Someya, T., Kuwasako, K., Takahashi, M., Fahu, H., Inoue, M., Harada, T., Watanabe, S., Terada, T., Kobayashi, N., Shirouzu, M., Kigawa, T., Tanaka, A., Sugano, S., Güntert, P., Yokoyama, S. & Muto, Y. Structural basis for the dual RNA-recognition modes of human Tra2-β RRM. Nucl. Acids Res. 39, 1538-1553 (2011)

PDB 2RRB NMR restraints

3llh bio r 500.jpg Yamashita, S., Nagata, T., Kawazoe, M., Takemoto, C., Kigawa, T, Güntert, P., Kobayashi, N., Terada, T., Shirouzu, M., Wakiyama, M., Muto, Y. & Yokoyama, S. Structures of the first and second double-stranded RNA-binding domains of human TAR RNA-binding protein. Protein Sci. 20, 118-130 (2011)

PDB 3LLH Structure factors

2cpn asym r 500.jpg Yamashita, S., Nagata, T., Kawazoe, M., Takemoto, C., Kigawa, T, Güntert, P., Kobayashi, N., Terada, T., Shirouzu, M., Wakiyama, M., Muto, Y. & Yokoyama, S. Structures of the first and second double-stranded RNA-binding domains of human TAR RNA-binding protein. Protein Sci. 20, 118-130 (2011)

PDB 2CPN NMR restraints

1j26 asym r 500 2.jpg Handa, Y., Hikawa, Y., Tochio, N., Kogure, H., Inoue, M., Koshiba, S., Güntert, P., Inoue, Y., Kigawa, T., Yokoyama, S. & Nameki, N. Solution structure of the mitochondrial protein ICT1 that is essential for cell vitality. J. Mol. Biol. 404, 260-273 (2010)

PDB 1J26

2rqo bio r 500.jpg Hamada, T., Matsunaga, S.,Fujiwara, M., Fujita, K., Hirota, H., Schmucki, R., Güntert, P. & Fusetani, N. Solution structure of polytheonamide B, a highly cytotoxic nonribosomal polypeptide from marine sponge. J. Am. Chem. Soc. 132, 12941–12945 (2010)

PDB 2RQO NMR restraints

2e61 bio r 500.jpg He, F., Umehara, T., Saito, K., Harada, T., Watanabe, S., Yobuki, T., Kigawa, T., Takahashi, M., Kuwasako, K., Tsuda, K., Matsuda, T., Aoki, M., Seki, E., Kobayashi, N., Güntert, P., Yokoyama, S. & Muto, Y. Structural insight into the zinc finger CW domain as a histone modification reader. Structure 18, 1127–1139 (2010)

PDB 2E61 NMR restraints

2kr6 asym r 500.jpg Sobhanifar, S., Schneider, B., Löhr, F., Gottstein, D., Ikeya, T., Filipek, S., Güntert, P., Bernhard, F. & Dötsch, V. Structural investigation of the C-terminal catalytic fragment of presenilin-1. Proc. Natl. Acad. Sci. USA 107, 9644–9649 (2010)

PDB 2KR6 NMR restraints

2kby asym r 500.jpg Coutandin, D., Löhr, F., Niesen, F. H., Ikeya, T., Weber, T. A., Schäfer, B., Bullock, A. N., Yang, A., Güntert, P. , Knapp, S., McKeon, F., Der Ou, H. & Dötsch, V. Conformational stability and activity of p73 require a second helix in the tetramerization domain. Cell Death Diff. 16, 1582–1589 (2009)

PDB 2KBY NMR restraints

2yue asym r 500.jpg He, F., Saito, K., Kobayashi, N., Harada, T., Watanabe, S., Kigawa, T, Güntert, P., Unzai, S., Muto, Y. & Yokoyama, S. Structural and functional characterization of the NHR1 domain of the Drosophila Neuralized E3 ligase in the Notch signaling pathway. J. Mol. Biol. 393, 478-495 (2009)

PDB 2YUE NMR restraints
PDB 2E63 NMR restraints

2klo asym r 500.jpg Khayrutdinov, B. I., Bae, W. J., Yun, Y. M., Lee, J. H., Tsuyama, T., Kim, J. J., Hwang, E., Ryu, K. S., Cheong, H. K., Cheong, C., Ko, J. S., Enomoto, T., Karplus, P. A., Güntert, P., Tada, S., Jeon, Y. H., Cho, Y. Structure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factors. Protein Sci. 18, 2252-2264 (2009)

PDB 2KLO NMR restraints
PDB 3A4C

2rqc asym r 500.jpg Tsuda, K., Kuwasako, K., Takahashi, M., Someya, T., Inoue, M., Terada, T., Kobayashi, N., Shirouzu, M., Kigawa, T., Tanaka, A., Sugano, S., Güntert, P., Muto, Y. & Yokoyama, S. Structural basis for the sequence specific RNA-recognition mechanism of human CUG-BP1 RRM3. Nucl. Acids Res. 37, 5151–5166 (2009)

PDB 2RQC NMR restraints
PDB 2RQ4 NMR restraints

2rpj asym r 500.jpg He, F., Dang, W., Saito, K., Watanabe, S., Kobayashi, N., Güntert, P., Kigawa, T, Tanaka, A., Muto, Y. & Yokoyama, S. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. Protein Sci. 18, 650–656 (2009)

PDB 2RPJ NMR restraints

2kak asym r 500.jpg Peroza, E. A., Schmucki, R., Güntert, P., Freisinger, E. & Zerbe O. The βE-domain of Wheat Ec-1 metallothionein: A metal-binding domain with a distinctive structure. J. Mol. Biol. 387, 207–218 (2009)

PDB 2KAK NMR restraints BMRB 16025

2rog asym r 500.jpg Sakakibara, D., Sasaki, A., Ikeya, T., Hamatsu, J., Hanashima, T., Mishima, M., Yoshimasu, M., Hayashi, N., Mikawa, T., Wälchli, M., Smith, B. O., Shirakawa, M., Güntert, P. & Ito, Y. Protein structure determination in living cells by in-cell NMR spectroscopy. Nature 458, 102-105 (2009)

PDB 2ROG NMR restraints BMRB 11037 (in-cell)
PDB 2ROE NMR restraints BMRB 11035 (in solution)

2e5s asym r 250.jpg He, F., Dang, W., Abe, C., Tsuda, K., Inoue, M., Watanabe, S., Kobayashi, N., Kigawa, T, Matsuda, T., Yabuki, T., Aoki, M., Seki, E., Harada, T., Tomabechi, Y., Terada, T., Shirouzu, M., Tanaka, A., Güntert, P., Muto, Y. & Yokoyama, S. Solution structure of the RNA binding domain in the human muscleblind-like protein 2. Protein Sci. 18, 80-91 (2009)

PDB 2E5S　NMR restraints

2e29 asym r 250.jpg Ohnishi, S. Pääkkönen, K., Koshiba, S., Tochio, N., Sato, M., Kobayashi, N., Harada, T., Watanabe, S., Muto, Y., Güntert, P., Tanaka, A., Kigawa, T. & Yokoyama, S. Solution structure of the GUCT domain from human RNA helicase II/Guβ reveals the RRM fold, but implausible RNA interactions. Proteins 74, 133–144 (2009)

PDB 2E29

2jz4 asym r 250.jpg Takeda, M., Sugimori, N., Torizawa, T., Terauchi, T., Ono, A. M., Yagi, H., Yamaguchi, Y., Kato, K., Ikeya, T., Jee, J., Güntert, P., Aceti, D. J., Markley, J. L. & Kainosho, M. Structure of the putative 32 kDa myrosinase binding protein from Arabidopsis (At3g16450.1) as determined by the SAIL-NMR method. FEBS J. 275, 5873–5884 (2008)

PDB 2JZ4 NMR restraints BMRB 15607

2ba3 asym r 250.jpg Yoshida, H., Furuya, N., Lin, Y. J., Güntert, P., Komano, T. & Kainosho, M. Structural basis of the role of the NikA ribbon-helix-helix domain in initiating bacterial conjugation. J. Mol. Biol. 384, 690–701 (2008)

PDB 2BA3 BMRB 15784

2jns asym r 250.jpg Lin, Y. J., Umehara, T., Inoue, M., Saito, K., Kigawa, T., Jang, M. K., Ozato, K., Yokoyama, S., Padmanabhan, B., Güntert, P. Solution structure of the extraterminal domain of the bromodomain-containing protein BRD4. Protein Sci. 17, 2174–2179 (2008)

PDB 2JNS BMRB 15125

2ron asym r 250.jpg Koglin, A., Löhr, F., Bernhard, F., Rogov, V. R., Frueh, D. P., Strieter, E. R., Mofid, M. R., Güntert, P., Wagner, G., Walsh, C. T., Marahiel, M. A. & Dötsch, V. Structural basis for the selectivity of the external thioesterase of the surfactin-synthetase. Nature 454, 907–911 (2008)

PDB 2RON NMR restraints (SrfTEII)
PDB 2K2Q NMR restraints (complex of SrfTEII and H state TycC3–PCP)

1whv asym r 250.jpg Nagata, T., Suzuki, S., Endo, R., Shirouzu, M., Terada, T., Inoue, M., Kigawa, T, Güntert, P., Hayashizaki, Y., Muto, Y. & Yokoyama, S. The RRM domain of poly(A)-specific ribonuclease (PARN) has a non-canonical binding site for mRNA cap analog recognition. Nucl. Acids Res. 36, 4754–4767 (2008)

PDB 1WHV (free form)
PDB 2ROK (cap-bound form)

2jw8 asym r 250.jpg Takeda, M., Chang, C. K., Ikeya, T., Güntert, P., Chang, Y. H., Hsu, Y. L., Huang, T. H. & Kainosho, M. Solution structure of the C-terminal dimerization domain of SARS coronavirus nucleocapsid protein determined by the SAIL-NMR method. J. Mol. Biol. 380, 608–622 (2008)

PDB 2JW8 BMRB 15511

2rne asym r 250.jpg Kuwasako, K., Takahashi, M., Tochio, N., Abe, C., Tsuda, K., Inoue, M., Terada, T., Shirouzu, M., Kobayashi, N., Kigawa, T., Taguchi, S., Tanaka, A., Hayashizaki, Y., Güntert, P., Muto, Y. & Yokoyama, S. Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode. Biochemistry 47, 6437–6450 (2008)

PDB 2RNE

2fho asym r 250.jpg Kuwasako, K., Dohmae, N., Inoue, M., Shirouzu, M., Taguchi, S., Güntert, P., Séraphin, B., Muto, Y. & Yokoyama, S. Complex assembly mechanism and an RNA-binding mode of the human p14-SF3b155 spliceosomal protein complex identified by NMR solution structure and functional analyses. Proteins 71, 1617–1636 (2008)

PDB 2FHO NMR restraints

2jo8 asym r 250.jpg Hwang, E., Ryu, K. S., Pääkkönen, K., Güntert, P., Cheong, H. K., Lim, D. S., Lee, J. O., Jeon, Y. H. & Cheong, C. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proc. Natl. Acad. Sci. USA. 104, 9236–9241 (2007)

PDB 2JO8 NMR restraints

2dwv asym r 250.jpg Ohnishi, S. Güntert, P., Koshiba, S., Tomizawa, T., Akasaka, R., Tochio, N., Sato, M., Inoue, M., Harada, T., Watanabe, S., Tanaka, T., Shirouzu, M., Kigawa, T. & Yokoyama, S. Solution structure of an atypical WW domain in a novel β-clam-like dimeric form. FEBS Lett. 581, 462–468 (2007)

PDB 2DWV

2dt6 asym r 250.jpg Kuwasako, K., He, F., Inoue, M., Tanaka, A., Sugano, S., Güntert, P., Muto, Y. & Yokoyama, S. Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP. Structure 14, 1677–1689 (2006)

PDB 2DT6 (SURP1)
PDB 2DT7 (SURP2-SF3a60)

2dcp asym r 250.jpg ENTH-VHS domain At3g16270(9-135) from Arabidopsis thaliana.

López-Méndez, B. & Güntert, P. Automated protein structure determination from NMR spectra. J. Am. Chem. Soc. 128, 13112–13122 (2006)

PDB 2DCP NMR restraints

Note: Automated structure determination with FLYA. Structure does not supersede the original deposition 1VDY.

2dcq asym r 250.jpg Rhodanese homology domain At3g16270(175-295) from Arabidopsis thaliana.

López-Méndez, B. & Güntert, P. Automated protein structure determination from NMR spectra. J. Am. Chem. Soc. 128, 13112–13122 (2006)

PDB 2DCQ NMR restraints

Note: Automated structure determination with FLYA. Structure does not supersede the original deposition 1VEE.

2dcr asym r 250.jpg Src homology domain 2 from the human feline sarcoma oncogene Fes.

López-Méndez, B. & Güntert, P. Automated protein structure determination from NMR spectra. J. Am. Chem. Soc. 128, 13112–13122 (2006)

PDB 2DCR NMR restraintsbr>Note: Automated structure determination with FLYA. Structure does not supersede the original deposition 1WQU.

2h3s asym r 250.jpg Jurt, S., Aemissegger, A., Güntert, P., Zerbe, O. & Hilvert, D. A photoswitchable miniprotein based on the sequence of avian pancreatic polypeptide. Angew. Chem. Int. Ed. 45, 6297-6300 (2006)

PDB 2H4B NMR restraints (cis-1-PP)
PDB 2H3S NMR restraints (cis-1-PP bound to DPC micelles)
PDB 2H3T NMR restraints (trans-1-PP bound to DPC micelles)

1wvo asym r 250.jpg Hamada, T., Ito, Y., Abe, T., Hayashi, F., Güntert, P., Inoue, M., Kigawa, T., Terada, T., Shirouzu, M., Yoshida, M., Tanaka, A., Sugano, S., Yokoyama, S. & Hirota, H. Solution structure of the antifreeze-like domain of human sialic acid synthase. Protein Sci. 15, 1010–1016 (2006)

PDB 1WVO NMR restraints

2agm asym r 250.jpg Aachmann, F. L., Svanem, B. I. G., Güntert, P., Petersen, S. B., Valla, S. & Wimmer, R. NMR structure of the R-module - A parallel β-roll subunit from an Azotobacter vinelandii mannuronan C-5 epimerase. J. Biol. Chem. 281, 7350–7356 (2006)

PDB 2AGM NMR restraints

2d21 asym r 250.jpg Stereo-array isotope labeled (SAIL) maltodextrin-binding protein MBP.

Kainosho, M., Torizawa, T., Iwashita, Y., Terauchi, T., Ono, A. M. & Güntert, P. Optimal isotope labeling for NMR protein structure determinations. Nature 440, 52–57 (2006)

PDB 2D21 BMRB 6807

1x02 asym r 250.jpg Stereo-array isotope labeled (SAIL) calmodulin.

Kainosho, M., Torizawa, T., Iwashita, Y., Terauchi, T., Ono, A. M. & Güntert, P. Optimal isotope labeling for NMR protein structure determinations. Nature 440, 52–57 (2006)

PDB 1X02 BMRB 6541

1wwq asym r 250.jpg Li, H., Inoue, M., Yabuki, T., Aoki, M., Seki, E., Matsuda, T., Nunokawa, E., Motoda, Y., Kobayashi, A., Terada, T., Shirouzu, M., Koshiba, S., Lin, Y. J., Güntert, P., Suzuki, H., Hayashizaki, Y., Kigawa, T. & Yokoyama, S. Solution structure of the mouse enhancer of rudimentary protein reveals a novel fold. J. Biomol. NMR 32, 329–334 (2005)

PDB 1WWQ

1wqu asym r 250.jpg Scott, A., Pantoja-Uceda, D., Koshiba, S., Inoue, M., Kigawa, T., Terada, T., Shirouzu, M., Tanaka, A., Sugano, S., Yokoyama, S. & Güntert, P. Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes. J. Biomol. NMR. 31, 357–361 (2005)

PDB 1WQU BMRB 6331

1n27 asym r 250.jpg Nameki, N., Tochio, N., Koshiba, S., Inoue, M., Yabuki, T., Aoki, M., Seki, E., Matsuda, T., Fujikura, Y., Saito, M., Ikari, M., Watanabe, M., Terada, T., Shirouzu, M., Yoshida, M., Hirota, H., Tanaka, A., Hayashizaki, Y., Güntert, P., Kigawa, T. & Yokoyama, S. Solution structure of the PWWP domain of the hepatoma-derived growth factor family. Protein Sci. 14, 756–764 (2005)

PDB 1N27

1u3m asym r 250.jpg Calzolai, L., Lysek, D. A., Pérez, D. R., Güntert, P. & Wüthrich, K. Prion protein NMR structures of chicken, turtle and frog. Proc. Natl. Acad. Sci. USA 102, 651–655 (2005)

PDB 1U3M NMR restraints BMRB 6269 (chicken PrP(121-225))
PDB 1U5L NMR restraints BMRB 6270 (turtle PrP(121-225))
PDB 1XU0 NMR restraints BMRB 6282 (frog PrP(90-222))

1xyj asym r 250.jpg Lysek, D. A., Schorn, C., Nivon, L. G., Esteve-Moya, V., Christen, B., Calzolai, L., von Schroetter, C., Fiorito, F., Herrmann, T., Güntert, P. & Wüthrich, K. Prion protein NMR structures of cat, dog, pig and sheep. Proc. Natl. Acad. Sci. USA 102, 640–645 (2005)

PDB 1XYJ NMR restraints BMRB 6377 (cat PrP(121-231))
PDB 1XYK NMR restraints BMRB 6378 (dog PrP(121-231))
PDB 1XYQ NMR restraints BMRB 6380 (pig PrP(121-231))
PDB 1XYU NMR restraints BMRB 6381 (sheep PrP[R168](121-231))
PDB 1Y2S BMRB 6403 (sheep PrP[H168](121-231))

1vex asym r 250.jpg Pääkkönen, K., Tossavainen, H., Permi, P., Rakkolainen, H., Rauvala, H., Raulo, E., Kilpeläinen, I. & Güntert, P. Solution structures of the first and fourth TSR domains of F-spondin. Proteins 64, 665–672 (2006)

PDB 1SZL　NMR restraints BMRB 6175 (TSR1)
PDB 1VEX (TSR4)

1vdy asym r 250.jpg ENTH-VHS domain At3g16270 from Arabidopsis thaliana.

PDB 1VDY BMRB 5928

1vd0 asym r 250.jpg Iwai, H., Forrer, P., Plückthun, A. & Güntert, P. NMR solution structure of the monomeric form of the bacteriophage λ capsid stabilizing protein gpD. J. Biomol. NMR. 31, 351–356 (2005)

PDB 1VD0 BMRB 4936

1vee asym r 250.jpg Pantoja-Uceda, D., López-Méndez, B., Koshiba, S., Inoue, M., Kigawa, T., Terada, T., Shirouzu, M., Tanaka, A., Seki, M., Shinozaki, K., Yokoyama, S. & Güntert, P. Solution structure of the rhodanese homology domain At4g01050(175–295) from Arabidopsis thaliana. Protein Sci. 14, 224–230 (2005)

PDB 1VEE BMRB 5929

1ukx asym r 250.jpg Nameki, N., Yoneyama, M., Koshiba, S., Tochio, N., Inoue, M., Seki, E., Matsuda, T., Tomo, Y., Harada, T., Saito, K., Kobayashi, N., Yabuki, T., Aoki, M., Nunokawa, E., Matsuda, N., Sakagami, N., Terada, T., Shirouzu, M., Yoshida, M., Hirota, H., Osanai, T., Tanaka, A., Arakawa, T., Carninci, P., Kawai, J., Hayashizaki, Y., Kinoshita, K., Güntert, P., Kigawa, T. & Yokoyama, S. Solution structure of the RWD domain of the mouse GCN2 protein. Protein Sci. 13, 2089–2100 (2004)

PDB 1UKX BMRB 6297

1q9g asym r 250.jpg Fernández, C., Hilty, C., Wider, G., Güntert, P. & Wüthrich, K. NMR structure of the integral membrane protein OmpX. J. Mol. Biol. 336, 1211–1221 (2004)

PDB 1Q9G BMRB 4936

1wln asym r 250.jpg FHA domain of mouse afadin 6.

PDB 1WLN

1pbu asym r 250.jpg Vanwetswinkel, S., Kriek, J., Andersen, G. R., Güntert, P., Dijk, P., Canters, G. W. & Siegal, G. Solution structure of the 162 residue C-terminal domain of human elongation factor 1Bγ. J. Biol. Chem. 278, 43443–43451 (2003)

PDB 1PBU NMR restraints BMRB 5628

1mo8 asym r 250.jpg Hilge, M., Siegal, G., Vuister, G. W., Güntert, P., Gloor, S. M. & Abrahams, J. P. ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase. Nat. Struct. Biol. 10, 468–474 (2003)

PDB 1MO7 BMRB 5577 (free form)
PDB 1MO8 BMRB 5576 (ATP-bound form)

1lg4 asym r 250.jpg Lührs, T., Riek, R., Güntert, P. & Wüthrich, K. NMR structure of the human doppel protein. J. Mol. Biol. 326, 1549–1557 (2003)

PDB 1LG4 NMR restraints BMRB 5145

1h0l asym r 250.jpg Zahn, R., Güntert, P. & Wüthrich, K. NMR structure of a variant human prion protein with two disulfide bonds. J. Mol. Biol. 326, 225–234 (2003)

PDB 1H0L NMR restraints BMRB 5378

1sr3 asym r 250.jpg Enggist, E., Thöny-Meyer, L., Güntert, P. & Pervushin, K. NMR structure of the heme chaperone CcmE reveals a new functional motif. Structure 10, 1551–1557 (2002)

PDB 1SR3 NMR restraints

1ls8 asym r 250.jpg Lee, D., Damberger, F. D., Peng, G., Horst, R., Güntert, P., Nikonova, L., Leal, W. S. & Wüthrich, K. NMR structure of the unliganded Bombyx mori pheromone-binding protein at physiological pH. FEBS Lett. 531, 314–318 (2002)

PDB 1LS8

1k9c asym r 250.jpg Ellgaard, L., Bettendorff, P., Braun, D., Herrmann, T., Fiorito, F., Jelesarov, I., Güntert, P., Helenius, A. & Wüthrich, K. NMR Structures of 36 and 73-residue fragments of the calreticulin P-domain. J. Mol. Biol. 322, 773–784 (2002)

PDB 1K9C NMR restraints BMRB 5204 (residues 189-261)
PDB 1K91 NMR restraints BMRB 5205 (residues 221-256)

1jas asym r 250.jpg Miura, T., Klaus, W., Ross, A., Güntert, P., Senn, H. The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. J. Biomol. NMR 22, 89–92 (2002)

PDB 1JAS NMR restraints BMRB 5038

1gm0 asym r 250.jpg Horst, R., Damberger, F., Luginbühl, P., Güntert, P., Peng, G., Nikonova, L., Leal, W. S. & Wüthrich, K. NMR structure reveals intramolecular regulation mechanism for pheromone binding and release. Proc. Natl. Acad. Sci. USA 98, 14374–14379 (2001)

PDB 1GM0 NMR restraints BMRB 4849

1hhn asym r 250.jpg Ellgaard, L., Riek, R., Herrmann, T., Güntert, P., Braun, D., Helenius, A. & Wüthrich, K. NMR structure of the calreticulin P-domain. Proc. Natl. Acad. Sci. USA 98, 3133–3138 (2001)

PDB 1HHN BMRB 4878

1e1g asym r 250.jpg Calzolai, L., Lysek, D. A., Güntert, P., von Schroetter, C., Riek, R., Zahn, R. & Wüthrich, K. NMR structures of three single-residue variants of the human prion protein. Proc. Natl. Acad. Sci. USA 97, 8340–8345 (2000)

PDB 1E1G NMR restraints BMRB 4736 (variant M166V)
PDB 1E1P NMR restraints (variant S170N)
PDB 1E1U NMR restraints BMRB 4620 (variant R220K)

1qjk asym r 250.jpg Riek, R., Prêcheur, B., Wang, Y., Wider, G., Güntert, P., Liu, A., Kägi, J. H. R. & Wüthrich, K. NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA. J. Mol. Biol. 291, 417–428 (1999)

PDB 1QJK NMR restraints (α domain)
PDB 1QJL NMR restraints (β domain)
BMRB 4363

1bf8 asym r 250.jpg Pellecchia, M., Güntert, P., Glockshuber, R. & Wüthrich, K. The NMR solution structure of the periplasmic chaperone FimC. Nature Struct. Biol. 5, 885–890 (1998)

PDB 1BF8 NMR restraints BMRB 4070

1oca asym r 250.jpg Ottiger, M., Zerbe, O., Güntert, P. & Wüthrich, K. The NMR solution conformation of unligated human Cyclophilin A. J. Mol. Biol. 272, 64–81 (1997)

PDB 1OCA NMR restraints

1wkt asym r 250.jpg Antuch, W., Güntert, P. & Wüthrich, K. Ancestral βγ-crystallin precursor structure in a yeast killer toxin. Nature Struct. Biol. 3, 662–665 (1996)

PDB 1WKT NMR restraints BMRB 5255

1tap asym r 250.jpg Antuch, W., Güntert, P., Billeter, M., Hawthorne, T., Grossenbacher, H. & Wüthrich, K. NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata. FEBS Lett. 352, 251–257 (1994)

PDB 1TAP NMR restraints

1dtk asym r 250.jpg Berndt, K. D., Güntert, P. & Wüthrich, K. The NMR solution structure of dendrotoxin K from the venom of Dendroaspis polylepis polylepis. J. Mol. Biol. 234, 735–750 (1993)

PDB 1DTK NMR restraints

1hic asym r 250.jpg Szyperski, T., Güntert, P., Stone, S. R. & Wüthrich, K. NMR solution structure of hirudin(1–51) and comparison with corresponding three-dimensional structures determined using the complete 65-residue hirudin polypeptide chain. J. Mol. Biol. 228, 1193–1205 (1992)

PDB 1HIC NMR restraintsBMRB 1128

1pit asym r 250.jpg Berndt, K. D., Güntert, P., Orbons, L. P. M. & Wüthrich, K. Determination of a high-quality NMR solution structure of the bovine pancreatic trypsin inhibitor (BPTI) and comparison with three crystal structures. J. Mol. Biol. 227, 757–775 (1992)

PDB 1PIT NMR restraints

2hoa asym r 250.jpg Güntert, P., Qian, Y. Q., Otting, G., Müller, M., Gehring, W. J. & Wüthrich K. Structure determination of the Antp(C39S) homeodomain from nuclear magnetic resonance data in solution using a novel strategy for the structure calculation with the programs DIANA, CALIBA, HABAS and GLOMSA. J. Mol. Biol. 217, 531–540 (1991)

PDB 2HOA

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