MAPPER
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| − | * Güntert, P., Salzmann, M., Braun, D. & Wüthrich, K. Sequence-specific NMR | + | * Güntert, P., Salzmann, M., Braun, D. & Wüthrich, K. Sequence-specific NMR assignments of proteins by global fragment mapping with the program MAPPER[http://www.bpc.uni-frankfurt.de/guentert/Intranet/Reprints/Guntert00.pdf .] [http://dx.doi.org/10.1023/A:1008318805889 J. Biomol. NMR 18, 129–137 (2000)] |
| − | : | + | :''Reports or publications of results obtained with MAPPER must cite this paper.'' |
Latest revision as of 18:49, 14 August 2009
Sequence-specific NMR assignment of proteins by global sequence mapping
MAPPER is a program for semiautomatic sequence-specific NMR assignment in proteins. The program uses an input of short fragments of sequentially neighboring residues, which have been assembled based on sequential NMR connectivities and for which either the CA and CB chemical shifts or data on the amino acid type from other sources are known. MAPPER then performs an exhaustive search for self-consistent simultaneous mappings of all these fragments onto the protein sequence. Compared to using only the individual mappings of the spectroscopically connected fragments, the global mapping adds a powerful new constraint, which results in resolving many otherwise intractable ambiguities.
Availability
- MAPPER is available free-of-charge. The current version is MAPPER 2.0.
References
- Güntert, P., Salzmann, M., Braun, D. & Wüthrich, K. Sequence-specific NMR assignments of proteins by global fragment mapping with the program MAPPER. J. Biomol. NMR 18, 129–137 (2000)
- Reports or publications of results obtained with MAPPER must cite this paper.
