DIANA

Distance geometry algorithm for NMR applications

DIANA was my first program for NMR structure calculation. DIANA uses the variable target function algorithm and implements the REDAC strategy of using redundant dihedral angle constraints in order to increase the convergence rate of the structure calculations.

Availability

• DIANA is no longer available or supported. Its functionality has been incoporated into the program packages DYANA and CYANA.

References

• Güntert, P., Braun, W. & Wüthrich, K. Efficient computation of three-dimensional protein structures in solution from nuclear magnetic resonance data using the program DIANA and the supporting programs CALIBA, HABAS and GLOMSA. J. Mol. Biol. 217, 517–530 (1991)

• Güntert, P. & Wüthrich K. Improved efficiency of protein structure calculations from NMR data using the program DIANA with redundant dihedral angle constraints. J. Biomol. NMR 1, 447–456 (1991)