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(→Seminar by Dr. Hélène Van Melckebeke (16.01.2009)) |
(→Seminar by Prof. Masatsune Kainosho (14.10.2008)) |
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===== Seminar by Prof. Masatsune Kainosho (14.10.2008) ===== | ===== Seminar by Prof. Masatsune Kainosho (14.10.2008) ===== | ||
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+ | :'''Recent progress in the SAIL approach to study side-chain conformations of proteins and protein complexes''' | ||
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+ | :''Prof. Dr. Masatsune Kainosho, Nagoya University and Tokyo Metropolitan University, Japan | ||
===== Seminar by Prof. Hideo Iwai (15.09.2008) ===== | ===== Seminar by Prof. Hideo Iwai (15.09.2008) ===== | ||
===== Seminar by Prof. Koichi Kato (03.07.2008) ===== | ===== Seminar by Prof. Koichi Kato (03.07.2008) ===== |
Revision as of 16:54, 21 January 2009
Contents |
2009
Seminar by Dr. Hélène Van Melckebeke (16.01.2009)
- High resolution structure of the HET-s(218-289) prion amyloid fibrils using solid-state NMR
- Dr. Hélène Van Melckebeke, Physical Chemistry, ETH Zürich, Switzerland
- Prions and amyloid fibrils are associated with several animal and human diseases. Despite the paramount importance of the structural aspects, no atomic resolution structure of a prion in its fibrillar state has been reported yet. Solid-state NMR is to date the only technique capable of obtaining the structure of such non-crystalline and non-soluble compounds. We have obtained the structure of amyloid fibrils produced in vitro from the prion-forming domain (residues 218-289) of the HET-s prion from the filamentous fungus Podospora anserina using solid-state NMR techniques. These results give a structural explanation of the stability of the HET-s(218-289) fibrils. In the presentation, both methodological and structural aspects will be discussed.
- Wasmer, C. Lange, A., Van Melckebeke, H., Siemer, A. B., Riek, R. & Meier, B. H. (2008). Amyloid fibrils of the HET-s(218–289) prion form a β solenoid with a triangular hydrophobic core. Science 319, 1523–1526.
2008
Seminar by Prof. Masatsune Kainosho (14.10.2008)
- Recent progress in the SAIL approach to study side-chain conformations of proteins and protein complexes
- Prof. Dr. Masatsune Kainosho, Nagoya University and Tokyo Metropolitan University, Japan